MethBank is a DNA methylome programming database that integrates the genome-wide single-base nucleotide methylomes of gametes and early embryos at multiple diverse stages in different model organisms.

MethBank features integration and visualization of high-resolution DNA methylomes as well as gene expression profiles and genetic polymorphisms.

Ongoing efforts are focused on incorporation of methylomes and related data from other organisms, providing an important resource for the epigenetic and developmental studies.

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Zebrafish (Danio rerio)

Number of methylated CG sites: view
  • sperm: 20,606,757
  • egg: 20,987,274
  • 16-cell: 18,948,935
  • 32-cell: 20,825,693
  • 64-cell: 17,836,722
  • 128-cell: 19,889,625
  • 1k-cell: 20,815,960
  • germ ring: 19,258,632
  • testis: 20,095,377
Number of Differentially Methylated Regions:
view
  • Sperm vs Egg: 53,680
  • 1k vs Egg: 51,886
  • 1k vs 57h: 95
  • 57h vs Egg: 36,004
Number of SNP sites: view
  • TU (female): 3,653,795
  • TL (male): 3,423,892
Number of expressed genes: view
  • 1k-cell: 12,168
  • germ ring: 12,129
  • sperm: 13,529
  • egg: 11,191
Number of CpG Islands: 8,768
Reference: Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell, 2013, 153(4):774-784.

Mouse (Mus musculus)

Number of methylated CG sites: view
  • sperm: 19,455,209
  • oocyte: 19,100,312
  • 2-cell: 19,844,915
  • 4-cell : 19,637,338
  • E7.5: 19,644,831
  • E6.5: 19,805,268,
  • ICM: 19,523,556
  • E13.5 female: 19,253,566
  • E13.5 male: 19,352,586
Number of Differentially Methylated Regions:
view
  • Sperm vs Oocyte: 2,000
Number of SNP sites: 2,561,574
Number of expressed genes: 18,259
Number of CpG Islands: 37,730
Reference: Programming and Inheritance of Parental DNA Methylomes in Mammals. Cell, 2014, 157(4): 979-991.

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